Abstract Gynandromorphs are individuals that display both male and female features throughout the body and are rarely found in nature. We document and describe two new gynandromorphs of the large carpenter bee Xylocopa (Neoxylocopa) augusti reared from a trap-nest in La Plata, Buenos Aires, Argentina. In addition, based on a literature review, we assessed the frequency of the different types of gynandromorphs, and the body part affected, among large carpenter bees. Both gynandromorphs were assigned to the mixed category, the most common category reported in the literature (22 of 25 specimens). The remaining three specimens exhibit a bilateral pattern in all tagmata. The presence of both sexes’ secondary sexual characteristics occurred more frequently on the mesosoma than on the head or metasoma. Trap nests used in bee hotels promote the conservation and study of wild bees and might facilitate the discovery of rare cases of gynandromorphs that would remain unknown otherwise under normal nesting conditions in the wild.

The conopid fly Physocephala inhabilis (Walker) is newly recorded as parasitoid of the native bee Megachile (Sayapis) bomplandensis (Durante). We also document an unidentified species of Physocephala parasitizing a Megachile (Chrysosarus) sp. in Argentina.

El conópido Physocephala inhabilis (Walker) es registrado como parasitoide de la abeja nativa Megachile (Sayapis) bomplandensis (Durante). También se reporta el hallazgo de una especie sin identificar del género Physocephala parasitando a Megachile (Chrysosarus) sp. en Argentina.

ABSTRACT Objective: To assess clinical outcomes of intolerant, relapsed or refractory patients who could not be treated with new tyrosine kinase inhibitors or experimental therapies. Methods: A retrospective cohort of 90 chronic myeloid leukemia patients in all phases of the disease treated with imatinib mesylate as their first TKI therapy, and with dasatinib or nilotinib as the next line of therapy. We evaluated clinical outcomes of these patients, with special focus on the group that needed more than two therapy lines. Results: Thirty-nine percent of patients were refractory or intolerant to imatinib. An 8-year overall survival rate of the patients who went through three or more lines of treatment was significantly lower, compared to those who were able to maintain imatinib as their first-line therapy (83% and 22%, respectively p < 0.01). Decreased overall survival was associated with advanced-phase disease (p < 0.01), failure to achieve major molecular response in first-line treatment (p < 0.01) and interruption of first-line treatment due to any reason (p = 0.023). Failure in achieving complete cytogenetic response and major molecular response and treatment interruption were associated with the progression to the third-line treatment. Conclusion: The critical outcome observed in relapsed, intolerant or refractory chronic phase CML patients reflects the unmet need for this group of patients without an alternative therapy, such as new drugs or experimental therapies in clinical trials. Broader access to newer treatment possibilities is a crucial asset to improve survival among CML patients, especially those refractory or intolerant to first-line therapies.

We report Leucospis leucotelus Walker parasitizing nests of Xylocopa (Schonnherria) lateralis Say in Colombia. Previous literature records of species of Leucospis associated with species o fXylocopa are summarized.

Registramos a Leucospis leucotelus Walker parasitando nidos de Xylocopa (Schonnherria) lateralis Say en Colombia. Además, recopilamos todos los registros previos citados en la bibliografía de especies d eLeucospis asociados a especies de Xylocopa.

Abstract Here we provide descriptions of gynandromorphs of two species oil-collecting bees: Lophopedia nigrispinis and Epicharis iheringii, both with partial bilateral phenotypic asymmetry. The bees have a female phenotype predominantly on mesosoma and metasoma. The specimen of L. nigrispinis has distinct characteristics on legs, suggesting a mosaic pattern of gynandromorphism. The pollen and oil loads on legs suggest that the bee was foraging normally. The gynander specimen of E. iheringii has mostly a female phenotype, except for head, with right half female type and left half male type. The specimen of L. nigrispinis was collected foraging on flowers of Bidens sp. at Parque Nacional Iguazú, Argentina with loads of pollen on legs suggesting it was reproductive and was provisioning a nest. The specimen of Epicharis iheriingi has no evidence of any oil or pollen collection, despite its mostly female phenotype.

RESUMEN Una especie nueva de Trigonisca es descrita para el Noroeste de Argentina, Trigonisca sachamiski sp. nov., la cual se distribuye en las provincias de Salta y Jujuy. Se presentan también mapas de distribución, notas comparativas y sinopsis de las especies de Nannotrigona y Lestrimelitta que están presentes en la Argentina. Nannotrigona melanocera y Lestrimelitta rufa son reportadas por primera vez para la Argentina y se presenta una clave para reconocer las cuatro especies registradas en la Argentina de Lestrimelitta.

ABSTRACT A new species of Trigonisca is described for northwestern Argentina, Trigonisca sachamiski sp. nov., of Salta and Jujuy provinces. Distribution maps, comparative notes and a synopsis of Nannotrigona and Lestrimelitta present in Argentina are also given. Nannotrigona melanocera and Lestrimelitta rufa are reported for the first time in Argentina and key is provided to four Argentinian species of Lestrimelitta.

O objetivo deste trabalho foi definir diretrizes para a indicação do transplante de células-tronco hematopoéticas (TCTH) no tratamento da leucemia mieloide aguda (LMA) no Brasil. O papel do TCTH no tratamento da LMA foi discutido pelosautores e apresentado para a Sociedade Brasileira de Transplante de Medula Óssea na reunião sobre Diretrizes Brasileiras para o TCTH, que o ratificou. Este consenso foi baseado na revisão da literatura internacional e na experiência brasileira em TCTH para o tratamento da LMA. O tratamento ideal para leucemia mieloide aguda em primeira remissão completa (1RC) ainda não está definido. Há consenso na indicação do TCTH alogênico, com condicionamento mieloablativo, para pacientes que apresentem alterações citogenéticas consideradas de alto risco. O TCTH alogênico não está indicado na 1RC para pacientes de baixo risco citogenético e, aparentemente, o TCTH alogênico, autólogo ou a quimioterapia de consolidação são equivalentes para os pacientes de risco intermediário.

The objective of this work was to define guidelines for the indication of hematopoietic stem cells transplantation (HSCT) in the treatment of acute myeloid leukemia (AML) in Brazil. The role of HSCT in the treatment of AML was discussed by the authors and presented to the Brazilian Society of Bone Marrow Transplantation in a meeting to formulate and ratify the Brazilian Guidelines on HSCT. This consensus was based on a review of international publications and on the Brazilian experience in HSCT for the treatment of AML. The optimal treatment for AML in first complete remission (1CR) has not been defined yet. There is consensus on the indication of allogeneic HSCT with myeloablative conditioning for patients who present high risk cytogenetic changes. Allogeneic HSCT is not indicated for low cytogenetic risk 1RC patients and, apparently, allogeneic and autologous HSCT and consolidation chemotherapy are similar for intermediate risk patients.

We describe a mixed gynandromorph of Xylocopa (Neoxylocopa) nigrocincta from a single specimen from Argentina. The specimen presents bilateral asymmetry, with the right half of its head displaying male characters and the left half displaying female characters; the mesosoma presents male characters mostly in the right half of the prothorax, pronotal lobe and distal half of the fore tibia and in the pubescence of tarsus; the rest of the mesosoma and the metasoma display female features

Se describe un ginandromorfo mixto de Xylocopa (Neoxylocopa) nigrocincta de un ejemplar de Argentina. El ginandromorfo tiene asimetría bilateral en la cabeza, con su mitad derecha con caracteres del macho y su mitad izquierda con caracteres de la hembra. El mesosoma presenta algunas características de macho en la mitad anterior derecha (protorax, lóbulo pronotal, mitad posterior de la protibia y pubescencia del tarso), el resto de meso y metasoma con caracteres de la hembra.

Seventeen species of Megachile (Dasymegachile) are recognized, twelve species from Chile, nine species from Argentina, three from Peru and one from Bolivia. Descriptions, illustrations, and keys for the identification for the Argentinean species are provided. The geographical distributions in Argentina are revised; M. cinerea and M. melanotricha are recorded for the first time from Argentina. Two species are also newly recorded from Chile.

Se reconocen 17 especies para el subgénero Megachile (Dasymegachile), de las cuales 12 se distribuyen en Chile, nueve en Argentina, tres en Perú y una en Bolivia. Se brindan descripciones, ilustraciones y claves para la identificación de las especies argentinas. Se revisan las distribuciones geográficas; M. cinerea y M. melanotricha, son citadas por primera vez para Argentina. Dos nuevas especies son citadas para Chile.

This study presents a taxonomic review of the Argentinean species of Bombus. Keys to identify female and male specimens at the species level [including the Palearctic species, Bombus (Megabombus) ruderatus] are given. Three subgenera are recognized: Fervidobombus, the most diversified, with six different species; Coccineobombus and Robustobombus each with one species. For each taxon, queen, worker and male descriptions are given, as well as the following information: morphological variation, comparative comments and geographic distribution. Also, for each taxon SEM photographs of male genitalia and drawings of female sting capsule are provided.

Este estudio es un análisis taxonómico de las especies argentinas de Bombus. Se proponen claves para la identificación de hembras y machos a nivel específico [incluyendo la especie paleártica Bombus (Megabombus) ruderatus]. Se reconocen tres subgéneros: Fervidobombus, el más diversificado, con seis especies diferentes; Coccineobombus y Robustobombus con una especie cada uno. Para cada taxón se incluye una descripción de reina, obrera y macho e información adicional sobre variaciones morfológicas, comentarios comparativos y distribución geográfica. Para cada especie se proporcionan fotografías tomadas al microscopio electrónico de barrido de los genitales del macho y dibujos de la cápsula del aguijón de hembra.